Changing the future of spinal cord injury
Janice Ng commenced her Nathalie Rose Barr funded PhD in 2018 at University of Leeds, working in the laboratory of Dr Jessica Kwok.
After completing a Diploma in Biotechnology in Singapore, Janice studied for her degree at University of Birmingham obtaining a BSc Hons in Biomedical Science with a focus on Neurotrauma, neuropharmacology, and cancer sciences.
Her PhD will investigate whether oral administration of a novel plasticity enhancer improves functional recovery after chronic spinal cord injury.
Oral administration of novel plasticity enhancer in chronic spinal cord injury
University of Leeds
In previous laboratory research, a small molecule called 'PNNi', already licensed for medical use, has been shown to reduce the growth inhibiting activity of perineuronal nets (PNN) in a normal spinal cord and, if given shortly after trauma, in acute spinal cord injury.
Researchers at Leeds University will now test if the oral administration of PNNi in an animal model is effective in
- decreasing PNN inhibitory activity
- enhancing axon sprouting
in chronic spinal cord injury when used alongside rehabilitation exercise to increase functional recovery.
Why neuroscience research in spinal cord injury is important to Janice
“What continues to captivate me about science is that it serves as a tool to provide sense into what might otherwise seem enigmatic - a prime example being the complex nature of our nervous system.
Research into spinal cord injury is of particular interest to me; despite its significant incidence worldwide, recovering complete motor capacity after such injuries remains out of reach for most patients.
Contributing to fundamental research on spinal cord injury could lead to major improvements in rehabilitation; and give hope to millions of patients around the world about the possibilities of recovery.”